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Recognition of enzymes lacking bound cofactor by protein quality control

October 2016. Newly synthetized enzymes must fold correctly and associate with cofactors to reach their functional state. Frankfurt scientists led by Martin Vabulas have now demonstrated that cofactor deprivation due to vitamin...


Novel insights into the replication mechanisms of the influenza virus

October 2016. Pre-initiation and initiation conformations of virus promoter RNA probed by single-molecule FRET


Light control of complex scenarios

October 2016. Three-dimensional control of DNA hybridization by orthogonal two-color two-photon uncaging


Unveiling the ubiquitin fingerprint induced by Salmonella infection.

September 2016. Bacterial invasion impacts several critical pathways of the host cell


Antigenic peptide recognition on the human ABC transporter TAP resolved by DNP-enhanced solid-state NMR spectroscopy

September 2016. The human transporter associated with antigen processing (TAP) selects peptides for export into the endoplasmic reticulum and subsequent loading onto major histocompatibility complex class I molecules to trigger...


New structural information on growing microtubule ends

September 2016. EB1 interacts with outwardly curved and straight regions of the microtubule lattice


New role of RNA editing in vascular disease

September 2016. Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation


Structure of a complete yeast ATP synthase dimer shows molecular basis of inner mitochondrial membrane morphology

August 2016. Previously unknown subunit architecture of the dimer interface in the membrane revealed


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