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News Archive

Extending the paradigm

December 2016. Coupled ATPase-adenylate kinase activity in ABC transporters

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Caging of long oligonucleotides

December 2016. New photo-tether strategy provides robust and versatile tool for the light-activation of longer functional oligonucleotides

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Further funding for Ub-Net

December 2016. LOEWE programme Ubiquitin Networks extended

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New ubiquitin chemistry regulates life processes

December 2016. Phosphoribosylation of ubiquitin promotes serine ubiquitination and impairs conventional ubiquitination

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DFG award for international marketing concept

December 2016. International marketing concept of UBAUT networks receives DFG award

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SFB 1080 funding extended

November 2016. €12 million for research in the Rhine-Main area on molecular and cellular mechanisms of neural homeostasis

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Structure of RNA polymerase I transcribing ribosomal DNA genes

November 2016. Structure with and without nucleic acids solved at 3.8 Å resolution by cryo-electron microscopy

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Resolving the end-point of protein production

November 2016. Structure of ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry

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Sweetening neurotransmitter receptors and other neuronal proteins

October 2016. Researchers discover a “sugar-code” for neuronal membrane proteins

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Recognition of enzymes lacking bound cofactor by protein quality control

October 2016. Newly synthetized enzymes must fold correctly and associate with cofactors to reach their functional state. Frankfurt scientists led by Martin Vabulas have now demonstrated that cofactor deprivation due to vitamin...

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Novel insights into the replication mechanisms of the influenza virus

October 2016. Pre-initiation and initiation conformations of virus promoter RNA probed by single-molecule FRET

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Light control of complex scenarios

October 2016. Three-dimensional control of DNA hybridization by orthogonal two-color two-photon uncaging

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Unveiling the ubiquitin fingerprint induced by Salmonella infection.

September 2016. Bacterial invasion impacts several critical pathways of the host cell

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Antigenic peptide recognition on the human ABC transporter TAP resolved by DNP-enhanced solid-state NMR spectroscopy

September 2016. The human transporter associated with antigen processing (TAP) selects peptides for export into the endoplasmic reticulum and subsequent loading onto major histocompatibility complex class I molecules to trigger...

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New structural information on growing microtubule ends

September 2016. EB1 interacts with outwardly curved and straight regions of the microtubule lattice

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New role of RNA editing in vascular disease

September 2016. Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

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Structure of a complete yeast ATP synthase dimer shows molecular basis of inner mitochondrial membrane morphology

August 2016. Previously unknown subunit architecture of the dimer interface in the membrane revealed

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New LOEWE collaborative project MegaSyn

July 2016. Can the unique synthetic principle of megasynthases be employed for the production of antibiotics and other drugs via biomimetic approaches?

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How yeast cells regulate their fat balance

June 2016. Cylinder-shaped structures measure saturated and unsaturated fatty acids

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Key mechanism facilitating ubiquitin chain assembly resolved

June 2016. The CUE domain of Cue1 aligns growing ubiquitin chains with ubiquitin-conjugating enzyme 7 for rapid elongation

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First atomic structure of a bacterial bd-type oxidase

April 2016. The structure and arrangement of the heme cofactors of bd oxidase bear little resemblance to those of other membrane-spanning oxidases

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Quality control in oocytes by p63 is based on a spring-loaded activation mechanism

April 2016. Mechanism revealed how p63 is kept inactive yet rapidly eliminates oocytes in response to a few DNA double strand breaks

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Important new tool for single-molecule localization microscopy

March 2016. New open source software establishes streamlined approach for designing and validating super-resolution microscopy experiments

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New EU project addresses diabetes with pancreas organoids

February 2016. Endocrine cells derived from human pancreas organoids for cell-based therapy of type 1 diabetes

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Quality of protein folding in cells is guided by synonymous codon usage

February 2016. NMR reveals multiple conformational and oxidation states of synonymous codon variants

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Uncovering the secrets of root growth

January 2016. Rules and self-organizing properties of post-embryonic plant organ cell division patterns

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Live-cell protein labelling with nanometre precision by cell squeezing

Efficient and minimally disruptive light-triggered tracing of native proteins and subsequent super-resolution imaging of live-cell phenomena.

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Ernst Stelzer receives Lennart Philipson Award

January 2016. Award recognizes outstanding contribution in technology innovation in the life sciences

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Roles of autophagy during tumorigenesis

January 2016. Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation in C. elegans

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Key protein in eukaryotic replication occurs in distinct populations

January 2016. The central scaffold protein PCNA appears in replicating mammalian cells as two populations of slow and fast diffusion

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3D Bioprinting

January 2016. New project aims at rewiring living cells by in situ-lateral organization of membrane receptors

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'Traceless’ protein tracing

January 2016. High-affinity trans-splicing directed by a minimal interaction pair

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